HLA-DQB 1 codon 57 and genetic susceptibility to Type 1 (insulin-dependent) diabetes mellitus in French children
نویسندگان
چکیده
منابع مشابه
Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.
The association of insulin-dependent diabetes mellitus (IDDM) with certain HLA alleles is well documented in pediatric patients. Whether a similar association is found in adult-on-set IDDM is not clear, although the disease occurs after the age of 20 in 50% of cases. HLA class II DRB1, DQA1, and DQB1 alleles were studied in 402 type I diabetics and 405 healthy controls (all Caucasian) using oli...
متن کاملHLA Class I and Genetic Susceptibility to Type 1 Diabetes
OBJECTIVE We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies wer...
متن کاملGenetic susceptibility to type 1 diabetes mellitus in humans.
Type 1 diabetes mellitus (DM 1A) is an autoimmune disease belonging to the most frequent chronic diseases of the childhood and young adults. DM 1A results from immune-mediated destruction of the insulin-producing beta cells of the pancreas. It is a genetically determined disease and many genes or genetic regions were found to be associated with its induction. In addition to the insulin-dependen...
متن کاملA Combination of HLA - DQ , # Asp 57 - Negative and HLA DQa Arg 52 Confers Susceptibility to Insulin - dependent Diabetes Mellitus
Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57 (Asp57) of the DQ/i chain is positively correlated to IDDM. However, Asp57-negative haplotypes do not always confer susceptibility and conversely, some Asp57-positive haplotypes seem to be disease a...
متن کاملGenetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region.
OBJECTIVES To test the hypothesis that the genetic susceptibility to non-insulin dependent diabetes mellitus is the same as that to insulin dependent disease and to see whether glucose intolerance is associated with specific HLA haplotypes. DESIGN Population based study of men in 1989 first tested for glucose tolerance in 1984. HLA haplotypes, including HLA-A, C, B, DR, and DQ, were defined s...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1990
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00404046